Spikezilla vs Typhon by Mega-Gojira
Whoa, Whoa, WHOA! Now who's this guy some other evil dude trying to kill Spikezilla?
Spikezilla maybe in over his head
Do you think that Zeus or Herakles (Hercules) could fight Tirek?
Maybe, but Tirek can fly (fast), so Herakles will have a tough time. Zeus may also have difficulty, because people keep referring the Princesses as Goddesses, so Tirek pretty much has the power equal to six gods (Celestia, Luna, Cadence, Twilight, himself, and All of Equestria).